Hydrinity: Where Regenerative Medicine Meets Skincare Innovation
From Wound Care to Aesthetics
When Keith O’Brien launched Hydrinity, it wasn’t with the intent to create a skincare company. His background is in regenerative medicine, wound care, spine surgery, and oncology — fields where healing quickly, balancing pH, and managing inflammation were matters of survival.
The lightbulb moment came when he realized the same principles that accelerate wound recovery could transform aesthetics. In his words, “We actually inflict wounds in aesthetics — lasers, microneedling, peels — and patients want healing, fast.” Hydrinity’s formulas carry over lessons from medicine into beauty, creating products designed not just to moisturize, but to repair and regenerate.
Beyond the Face: Science-Driven Body Care
Hydrinity’s move into body care wasn’t just a pivot — it was a response to an unmet need. The body makes up 90% of our skin surface, yet most body products are simply repackaged facial creams. As Keith explains, “Body skin is four times thicker than facial skin, with a turnover closer to 28 days instead of 14. You can’t just use a bigger bottle of face cream.”
With their Encore Body Hydrator, Hydrinity leveraged its proprietary low molecular weight HA delivery system to penetrate deeper and target the dermal layer where true regeneration occurs. By pairing this with high-dose antioxidantslike Kakadu plum–derived vitamin C, the product not only hydrates but also strengthens skin against oxidative stress.
Regenerative Principles: Balancing pH and Fighting Inflammation
Two pillars run through every Hydrinity product:
- pH balance: Just as wounds won’t heal without the right pH, skin cannot thrive if its balance is off.
- Inflammation control: Acute inflammation is normal, but prolonged inflammation accelerates aging, increases scarring, and disrupts skin renewal. Hydrinity formulations are designed to be inherently anti-inflammatory, helping skin recover from both environmental stressors and professional treatments.
This cross-pollination of regenerative medicine and aesthetics gives Hydrinity an edge: science first, skincare second.
Science Meets Luxury
For Keith, efficacy comes first, but sensory experience is a close third. “If it doesn’t feel good, people won’t keep using it,” he says. Hydrinity products avoid fragrances, dyes, and unnecessary fillers, instead focusing on clean formulations that glide on, absorb quickly, and deliver results. The philosophy is simple: science should feel like self-care.
A New Era of Retinal Therapy
Perhaps the most exciting innovation from Hydrinity is its new biomimetic exosome-encapsulated retinal, RetaXome™. Keith describes it as the “new gold standard” in retinol therapy:
- Potent yet gentle: It’s a true retinol (not a derivative), 10x stronger than retinol esters, but requires no titration.
- Clinically proven: In 12-week studies, patients saw a 58% reduction in redness (erythema) — a breakthrough since most retinoids causeirritation.
- Hydrating: With high concentrations of HA, patients experienced a 44% increase in hydration within 2 weeks.
- Inclusive: Tested across all Fitzpatrick skin types (I–VI), the trials reported zero dropouts due to irritation.
Encapsulated in stable, biomimetic exosomes, the retinal reaches the dermal layer intact, where it stimulates collagen and elastin without the oxidative breakdown typical of traditional formulas.
What This Means for Skincare
By marrying biotech innovation with clinical rigor, Hydrinity is reimagining both face and body care. Their approach emphasizes healing, regeneration, and consistency over hype, while ensuring products are enjoyable enough to use every day.
As Keith puts it: “Consistency is the secret to great skin. Whatever you use, use it morning and night. If you’re consistent, the results will come.”
Hydrinity is betting that when science and luxury truly meet, they can redefine how we think about skincare — from wound care origins to the future of regenerative aesthetics.
✨ Listen to the full episode of Skin Anarchy to hear Keith O’Brien dive deeper into Hydrinity’s innovations and what’s next in regenerative skincare.